| Iupac name | [4-(5-Acetyloxy-1-ethyl-3-methylindol-2-yl)phenyl] acetate |
|---|---|
| Width | 250 |
| Cas number | 86111-26-4 |
| Pubchem | 65645 |
| Chemspiderid | 59082 |
| Unii | 1IRS95M8DN |
| Kegg | C14745 |
| Chebi | 35052 |
| Chembl | 32227 |
| C | 21 |
| H | 21 |
| N | 1 |
| O | 4 |
| Smiles | CCN1C2=C(C=C(C=C2)OC(=O)C)C(=C1C3=CC=C(C=C3)OC(=O)C)C |
| Stdinchi | 1S/C21H21NO4/c1-5-22-20-11-10-18(26-15(4)24)12-19(20)13(2)21(22)16-6-8-17(9-7-16)25-14(3)23/h6-12H,5H2,1-4H3 |
| Stdinchikey | KSZGVNZSUJHOJA-UHFFFAOYSA-N |
| Synonyms | D-16726; NSC-341952 |
Zindoxifene (INN; former developmental code names D-16726, NSC-341952) is a nonsteroidal selective estrogen receptor modulator (SERM) that was under development in the 1980s and early 1990s for the treatment of breast cancer but was not marketed.[1] It showed estrogenic-like activity in preclinical studies and failed to demonstrate effectiveness as a treatment for breast cancer in clinical trials.[2][3] Zindoxifene was the lead compound of the distinct 2-phenylindole class of SERMs,[4][5] and the marketed SERM bazedoxifene was derived from the major active metabolite of zindoxifene, D-15414.[2][3] Zindoxifene was first described in 1984.[1]
References
- ^ Elks J (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 1300–. ISBN 978-1-4757-2085-3.
- ^ Maximov PY, McDaniel RE, Jordan VC (23 July 2013). "The Legacy of Tamoxifen". Tamoxifen: Pioneering Medicine in Breast Cancer. Springer Science & Business Media. pp. 170–. ISBN 978-3-0348-0664-0.
- ^ McDaniel R, Maximov PY, Jordan VC (25 June 2013). "The Legacy of Tamoxifen". Hormones and Breast Cancer. Elsevier. pp. 32–. ISBN 978-0-12-416676-9.
- ^ Oettel M, Schillinger E (6 December 2012). Estrogens and Antiestrogens I: Physiology and Mechanisms of Action of Estrogens and Antiestrogens. Springer Science & Business Media. pp. 68–69. ISBN 978-3-642-58616-3.
- ^ Maggi A, Paoletti R (2002). "The Pharmacological Modulations of Estrogen Receptor Activity". International position paper on women's health and menopause : a comprehensive approach. DIANE Publishing. pp. 111–. ISBN 978-1-4289-0521-4.