Penamecillin
Verifiedfieldschanged
Watchedfieldschanged
Verifiedrevid448868650
Iupac name(acetyloxy)methyl (2S,5R,6R)-3,3-dimethyl-7-oxo-6-[(phenylacetyl)amino]-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
Cas number983-85-7
Atc prefixJ01
Atc suffixCE06
Pubchem13795
UniiH0P1YE5581
Chebi131733
KeggD05406
Chemspiderid8426255
C19
H22
N2
O6
S1
SmilesCC(=O)OCOC(=O)[C@H]1C(S[C@H]2N1C(=O)[C@H]2NC(=O)CC3=CC=CC=C3)(C)C
Stdinchi1S/C19H22N2O6S/c1-11(22)26-10-27-18(25)15-19(2,3)28-17-14(16(24)21(15)17)20-13(23)9-12-7-5-4-6-8-12/h4-8,14-15,17H,9-10H2,1-3H3,(H,20,23)/t14-,15+,17-/m1/s1
StdinchikeyNLOOMWLTUVBWAW-HLLBOEOZSA-N

Penamecillin, an acetoxymethyl ester of benzylpenicillin, is a prodrug processed to benzylpenicillin by esterases.[1] It has no detectable teratogenic risk to the fetus.[2]

References

  1. ^ Agersborg HP, Batchelor A, Cambridge GW, Rule AW (March 1966). "The pharmacology of penamecillin". British Journal of Pharmacology and Chemotherapy. 26 (3): 649–655. doi:10.1111/j.1476-5381.1966.tb01844.x. PMC 1510697. PMID 4959939
  2. ^ Czeizel AE, Rockenbauer M, Sørensen HT, Olsen J (1999). "The Safety of Penicillin V: Oral Penamecillin Use During Pregnancy The Importance and Limitation of Recall Bias". Congenital Anomalies. 39 (4): 267–279. doi:10.1111/j.1741-4520.1999.tb00566.x. ISSN 0914-3505