Protein tyrosine phosphatase receptor type C-associated protein is an enzyme that in humans is encoded by the PTPRCAP gene.[1]

The protein encoded by this gene was identified as a transmembrane phosphoprotein specifically associated with tyrosine phosphatase PTPRC/CD45, a key regulator of T- and B-lymphocyte activation. The interaction with PTPRC may be required for the stable expression of this protein.[1]

References

  1. ^ "Entrez Gene: PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein"

Further reading

  • Schraven B; Schoenhaut D; Bruyns E; Koretzky, G; Eckerskorn, C; Wallich, R; Kirchgessner, H; Sakorafas, P; Labkovsky, B (1994). "LPAP, a novel 32-kDa phosphoprotein that interacts with CD45 in human lymphocytes". J. Biol. Chem.. 269 (46): 29102–11. doi:10.1016/S0021-9258(19)62018-1. PMID 7961877
  • Bruyns E; Hendricks-Taylor LR; Meuer S; Koretzky, GA; Schraven, B (1996). "Identification of the sites of interaction between lymphocyte phosphatase-associated phosphoprotein (LPAP) and CD45". J. Biol. Chem.. 270 (52): 31372–6. doi:10.1074/jbc.270.52.31372. PMID 8537410
  • Bruyns E; Mincheva A; Bruyns RM; Kirchgessner, Henning; Weitz, Sandra; Lichter, Peter; Meuer, Stefan; Schraven, Burkhart (1997). "Sequence, genomic organization, and chromosomal localization of the human LPAP (PTPRCAP) and mouse CD45-AP/LSM-1 genes". Genomics. 38 (1): 79–83. doi:10.1006/geno.1996.0595. PMID 8954783
  • Kung C; Okumura M; Seavitt JR; Noll, Michelle E.; White, Lynn S.; Pingel, Jeanette T.; Thomas, Matthew L. (2000). "CD45-associated protein is not essential for the regulation of antigen receptor-mediated signal transduction". Eur. J. Immunol.. 29 (12): 3951–5. doi:10.1002/(SICI)1521-4141(199912)29:12<3951::AID-IMMU3951>3.0.CO;2-9. PMID 10602003. S2CID 4962507
  • Woods ML; Kivens WJ; Adelsman MA; Qiu, Yun; August, Avery; Shimizu, Yoji (2001). "A novel function for the Tec family tyrosine kinase Itk in activation of β1 integrins by the T-cell receptor". EMBO J.. 20 (6): 1232–44. doi:10.1093/emboj/20.6.1232. PMC 145515. PMID 11250890
  • Kirchgessner H; Dietrich J; Scherer J; Isomaki, P.; Korinek, V.; Hilgert, I.; Bruyns, E.; Leo, A.; Cope, A. P. (2001). "The Transmembrane Adaptor Protein Trim Regulates T Cell Receptor (Tcr) Expression and Tcr-Mediated Signaling via an Association with the Tcr ζ Chain". J. Exp. Med.. 193 (11): 1269–84. doi:10.1084/jem.193.11.1269. PMC 2193385. PMID 11390434
  • Strausberg RL; Feingold EA; Grouse LH; Derge, JG; Klausner, RD; Collins, FS; Wagner, L; Shenmen, CM; Schuler, GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932
  • Vogel A, Strassburg CP, Manns MP (2003). "77 C/G mutation in the tyrosine phosphatase CD45 gene and autoimmune hepatitis: evidence for a genetic link". Genes Immun.. 4 (1): 79–81. doi:10.1038/sj.gene.6363918. PMID 12595907. S2CID 19853676
  • Cocco E; Murru MR; Melis C; Schirru, Lucia; Solla, Elisabetta; Lai, Marina; Rolesu, Marcella; Marrosu, Mariagiovanna (2004). "PTPRC (CD45) C77G mutation does not contribute to multiple sclerosis susceptibility in Sardinian patients". J. Neurol.. 251 (9): 1085–8. doi:10.1007/s00415-004-0485-1. PMID 15372250. S2CID 35718298
  • Gerhard DS; Wagner L; Feingold EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S; Rasooly, R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res.. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334