PPP3R1

Calcineurin subunit B type 1 also known as protein phosphatase 2B regulatory subunit 1 is a protein that in humans is encoded by the PPP3R1 gene.^[1][2][3]

Clinical significance

The presence of a single nucleotide polymorphism rs1868402 in the PPP3R1 gene is strongly correlated with rapid progress of Alzheimer's disease.^[4]

References

1. ^ Wang MG, Yi H, Guerini D, Klee CB, McBride OW (Jan 1997). "Calcineurin A alpha (PPP3CA), calcineurin A beta (PPP3CB) and calcineurin B (PPP3R1) are located on human chromosomes 4, 10q21→q22 and 2p16→p15 respectively". Cytogenet Cell Genet. 72 (2–3): 236–41. doi:10.1159/000134198. PMID 8978785
2. ^ Guerini D, Krinks MH, Sikela JM, Hahn WE, Klee CB (Mar 1990). "Isolation and sequence of a cDNA clone for human calcineurin B, the Ca2+-binding subunit of the Ca2+/calmodulin-stimulated protein phosphatase". DNA. 8 (9): 675–82. doi:10.1089/dna.1.1989.8.675. PMID 2558868
3. ^ "Entrez Gene: PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform"
4. ^ Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, etal (2010). "SNPs Associated with Cerebrospinal Fluid Phospho-Tau Levels Influence Rate of Decline in Alzheimer's Disease". PLOS Genet. 6 (9). doi:10.1371/journal.pgen.1001101. PMC 2940763. PMID 20862329

Further reading

• Kawamura A, Su MS (1995). "Interaction of FKBP12-FK506 with calcineurin A at the B subunit-binding domain.". J. Biol. Chem.. 270 (26): 15463–6. doi:10.1074/jbc.270.26.15463. PMID 7541044
• Kissinger CR, Parge HE, Knighton DR, etal (1996). "Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex.". Nature. 378 (6557): 641–4. Bibcode:1995Natur.378..641K. doi:10.1038/378641a0. PMID 8524402. S2CID 4337105
• Feng B, Stemmer PM (1999). "Interactions of calcineurin A, calcineurin B, and Ca2+.". Biochemistry. 38 (38): 12481–9. doi:10.1021/bi990492w. PMID 10493818
• Stratakis CA, Taymans SE (1999). "Structure of the gene coding for calcineurin B (PPP3R1) and mapping to D2S358-D2S1778 (chromosomal region 2p15).". DNA Seq.. 9 (4): 227–30. doi:10.3109/10425179809105209. PMID 10520753
• Nishio H, Matsui K, Tsuji H, etal (2000). "Immunolocalization of calcineurin and FKBP12, the FK506-binding protein, in Hassall's corpuscles of human thymus and epidermis.". Histochem. Cell Biol.. 114 (1): 9–14. doi:10.1007/s004180000168. PMID 10959817. S2CID 21530150
• Sokal I, Li N, Verlinde CL, etal (2001). "Ca(2+)-binding proteins in the retina: from discovery to etiology of human disease(1).". Biochim. Biophys. Acta. 1498 (2–3): 233–51. doi:10.1016/S0167-4889(00)00099-9. PMID 11108966
• Graef IA, Chen F, Chen L, etal (2001). "Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature.". Cell. 105 (7): 863–75. doi:10.1016/S0092-8674(01)00396-8. PMID 11439183. S2CID 5278706
• Al-Daraji WI, Grant KR, Ryan K, etal (2002). "Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A.". J. Invest. Dermatol.. 118 (5): 779–88. doi:10.1046/j.1523-1747.2002.01709.x. PMID 11982754
• Huai Q, Kim HY, Liu Y, etal (2002). "Crystal structure of calcineurin-cyclophilin-cyclosporin shows common but distinct recognition of immunophilin-drug complexes.". Proc. Natl. Acad. Sci. U.S.A.. 99 (19): 12037–42. Bibcode:2002PNAS...9912037H. doi:10.1073/pnas.192206699. PMC 129394. PMID 12218175
• Jin L, Harrison SC (2002). "Crystal structure of human calcineurin complexed with cyclosporin A and human cyclophilin.". Proc. Natl. Acad. Sci. U.S.A.. 99 (21): 13522–6. Bibcode:2002PNAS...9913522J. doi:10.1073/pnas.212504399. PMC 129706. PMID 12357034
• Strausberg RL, Feingold EA, Grouse LH, etal (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A.. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932
• Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2003). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha.". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669
• Gerhard DS, Wagner L, Feingold EA, etal (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res.. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334
• Bittinger MA, McWhinnie E, Meltzer J, etal (2005). "Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins.". Curr. Biol.. 14 (23): 2156–61. doi:10.1016/j.cub.2004.11.002. PMID 15589160. S2CID 5934014
• Hillier LW, Graves TA, Fulton RS, etal (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4.". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi:10.1038/nature03466. PMID 15815621
• Rual JF, Venkatesan K, Hao T, etal (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026
• Winslow MM, Gallo EM, Neilson JR, Crabtree GR (2006). "The calcineurin phosphatase complex modulates immunogenic B cell responses.". Immunity. 24 (2): 141–52. doi:10.1016/j.immuni.2005.12.013. PMID 16473827
• Liu Q, Wilkins BJ, Lee YJ, etal (2006). "Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth.". Mol. Cell. Biol.. 26 (10): 3785–97. doi:10.1128/MCB.26.10.3785-3797.2006. PMC 1489013. PMID 16648474