| State | MO |
|---|---|
| Route | 38 |
| Length | 80.561 mi |
| Direction b | East |
| Direction a | West |
| Terminus b | west of Houston |
| Junction | in Marshfield |
| Terminus a | south of Buffalo |
| Previous route | 37 |
| Next route | 39 |
Route 38 is a highway in southern Missouri. Its eastern terminus is at Route 17 10 miles (16 km) west of Houston; its western terminus is at U.S. Route 65 about 10 miles (16 km) south of Buffalo.