Mapuá, Māpua or Mapúa may refer to:
- Mapuá River, a river in Pará state in north-central Brazil
- Mapuá Extractive Reserve, a protected area
- Treaty of the Mapuá, a treaty between the Portuguese and indigenous groups
- Māpua, New Zealand, a small town on the South Island of New Zealand
- Tomás Mapúa, the first registered Filipino architect and founder of Mapúa University
- Mapúa University, a tertiary institute in Manila, Philippines
- Mapúa Cardinals, varsity teams of the university