| State | ME |
|---|---|
| Route | 22 |
| Length | 19.48 mi |
| Length round | 2 |
| Direction a | West |
| Terminus a | in Buxton |
| Direction b | East |
| Junction | |
| Terminus b | in Portland |
| Counties | York, Cumberland |
| Established | 1939, 1958 (current alignment) |
| Previous route | 18 |
| Next route | 23 |
State Route 22 (SR 22) is a 19.4-mile (31.2-kilometre) state highway located in southwestern Maine. It serves the western suburbs of Portland, running from SR 35 in Buxton east into the city, where it ends at SR 77.