Isham Talbot
Jr/sr 1United States Senator
State 1Kentucky
Term start 1February 2, 1815
Term end 1March 4, 1819
Predecessor 1Jesse Bledsoe
Successor 1William Logan
Term start 2October 19, 1820
Term end 2March 4, 1825
Predecessor 2William Logan
Successor 2John Rowan
Office 3Member of the Kentucky Senate
Term 31812–1815
Birth date1773
Birth placeBedford County, Virginia
Death dateSeptember 25, 1837 (aged 63–64)
Death placeFrankfort, Kentucky
Resting placeFrankfort Cemetery
PartyDemocratic-Republican

Isham Talbot (1773 – September 25, 1837) was a United States Senator from Kentucky.

Born in Bedford County, Virginia, Isham Talbot Jr. moved with his parents, Isham and Elizabeth (Davis) Talbot, to Harrodsburg, Kentucky in about 1784. He was admitted to the bar, and began his legal practice in Versailles, Kentucky. He moved to Frankfort, Kentucky, where he also was a lawyer.

Talbot served in the Kentucky Senate from 1812 to 1815. He was then elected as a Democratic Republican to the United States Senate to fill the vacancy caused by the resignation of Senator Jesse Bledsoe, and served from February 2, 1815, to March 3, 1819. The second time he was elected to the United States Senate was to fill the vacancy caused by the resignation of William Logan, and served from October 19, 1820, to March 3, 1825. He then resumed his law practice and died on his plantation near Frankfort.

Isham Talbot was interred in the State Cemetery in Frankfort.

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