| Width | 165px |
|---|---|
| Class | Serotonin receptor modulator; Serotonin 5-HT2A receptor agonist |
| Atc prefix | None |
| Pubchem | 166091994 |
| Synonyms | Fluoro-PRO-LAD; F-PRO-LAD; Fluoropropyl-LAD; PROFLAD; PROF-LAD; TRALA-16; 6-(3-Fluoropropyl)-6-nor-LSD; (8β)-N,N-Diethyl-6-(3-fluoropropyl)-9,10-didehydroergoline-8-carboxamide |
| Iupac name | (6aR,9R)-N,N-diethyl-7-(3-fluoropropyl)-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide |
| C | 22 |
| H | 28 |
| F | 1 |
| N | 3 |
| O | 1 |
| Smiles | CCN(CC)C(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)CCCF |
| Stdinchi | 1S/C22H28FN3O/c1-3-25(4-2)22(27)16-11-18-17-7-5-8-19-21(17)15(13-24-19)12-20(18)26(14-16)10-6-9-23/h5,7-8,11,13,16,20,24H,3-4,6,9-10,12,14H2,1-2H3/t16-,20-/m1/s1 |
| Stdinchikey | BFFBEQKSDONILF-OXQOHEQNSA-N |
FP-LAD, also known as fluoro-PRO-LAD, PROF-LAD, or TRALA-16, is a serotonin receptor modulator of the lysergamide family related to lysergic acid diethylamide (LSD; METH-LAD).[1] It is specifically a fluorinated derivative of PRO-LAD (6-propyl-6-nor-LSD) and an analogue of FLUORETH-LAD (FE-LAD; 6-ethyl-6-nor-LSD).[1]
The drug has been reported to act as a potent ligand of the serotonin 5-HT2 receptors.[1] It had affinities (Ki) of 0.93 nM at the serotonin 5-HT2A receptor, 1.8 nM at the serotonin 5-HT2B receptor, and 3.7 nM at the serotonin 5-HT2C receptor.[1] FP-LAD was assessed and found to be a full agonist of the serotonin 5-HT2A and 5-HT2C receptors, with EC50 and Emax values of 0.48 nM (93%) and 1.7 nM (97%), respectively.[1] It had several-fold greater activational potency than LSD at the serotonin 5-HT2A and 5-HT2C receptors.[1]
The chemical synthesis of FP-LAD has been described.[1]
FP-LAD was patented by Daniel Trachsel and Matthias Liechti and colleagues in association with MindMed (Mind Medicine) in 2023.[1] It had also previously been described in an earlier patent by Andrew Kruegel in association with Gilgamesh Pharmaceuticals in 2022.[2] Hamilton Morris has described synthesizing FP-LAD and/or 1P-FP-LAD (1P-PROF-LAD or 1P-PROFLAD) with Lizard Labs in 2025.[3][4][5] According to Morris, FP-LAD was active but had only about one-fifth of the potency of LSD.[5]
See also
References
- ^ "Lysergic acid derivatives with modified LSD-like action". No. 2023/0414583.
- ^ "Novel ergolines and methods of treating mood disorders". No. 2022226408A1. Example 13: Preparation of (6aR,9R)-N,N-diethyl-7-(cyclopropylmethyl)-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide (13) [...]
- ^ Andrew Callaghan (27 September 2025). "The Fight for Legal Psychedelics (#12)". Channel 5 with Andrew Callaghan. YouTube. pp. 1:14:26–1:15:32.
[...] I just made a really interesting variant of LSD. I don't know if I have to bleep this out, but it was propyl-fluoro-1-propionyl-nor-LSD. And 6-propylfluoro. [...]
- ^ Adam Jay Moskowitz (2 October 2025). "Drug Journalist Hamilton Morris on Why All Drugs Should Be Legal". A Cheese Course. YouTube. pp. 29:48–31:12.
[...]
- ^ Hamilton Morris (13 July 2025). "POD 128: Dr. Daniel Panaccione on a newly discovered lysergamide producing fungus". The Hamilton Morris Podcast. Patreon. pp. ~58:20.