Central Hotel may refer to:
Australia
- Central Hotel, Cairns, Queensland, Australia, a heritage-listed building
- Central Hotel, Stanthorpe, Queensland, Australia, a heritage-listed building
Germany
- Central-Hotel, former hotel in Berlin at Friedrichstraße
Ireland
- Central Hotel fire, Bundoran, Co Donegal, Ireland
United Kingdom
- Central Hotel (Glasgow), Scotland
- Central Hotel, Douglas, Isle of Man, one of Isle of Man's Registered Buildings
United States
- Central Hotel (Mount Joy, Pennsylvania), listed on the National Register of Historic Places